Tag: #natural

7 Powerful Ingredients Found in ageLOC Youth

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Have you ever wondered about the power behind ageLOC Youth’s ingredient blend? Acquiring LifeGen gave us exclusive ownership of a large anti-aging gene expression database. This proprietary knowledge has led to a deeper understanding of gene expression and the way specific ingredients target and modulate gene expression.
Using our proprietary gene expression research and the most robust anti-aging scientific literature, we selected ingredients based on their unique health benefits and their ability to positively impact gene expression related to our aging defense mechanisms. This led to the development our most advanced anti-aging supplement, ageLOC Youth.

PURPLE CORN

According to archeological findings, purple corn has been a staple food for thousands of years in the Andean Mountain Region of South America. Even in modern day, Peruvian people use purple corn to make a beverage called “chicha morada.” Did you know the purple color comes from its anthocyanin content, a health promoting compound? Some of the key contributions of purple corn include cellular health, heart health, and metabolic health.

QUERCETIN
Quercetin is found in apples, blueberries, and blackberries, but is particularly high in onions. It helps blood vessels to relax, an important part of our bodies stress response. Some of the key contributions of quercetin include heart health, joint health, and metabolic health.

CITRUS BIOFLAVONOIDS
Citrus Bioflavonoids contribute to brain health, cellular health, and heart health benefits. Citrus peels are comprised of two distinct parts: the outer most colorful layer known as the zest, and the white spongy portion of the peel below the colorful zest where the citrus bioflavonoids primarily reside. Two principle bioflavonoids are known as hesperidin and naringin.

FISH OIL

Fish oil provides some key benefits including eye health, joint health, physical performance, and immune health. Did you know the highest concentration of the omega 3 DHA is found in the retina of the eye and in the brain? The fish oil in ageLOC Youth is in a concentrated form in order to fit all of the ingredients in as few capsules as possible.

LYCOPENE

Lycopene in the diet comes from tomatoes, guava, watermelon, and notably the gac fruit. The Mediterranean region is noted for its high tomato consumption. Lycopene is part of a family of antioxidants called “carotenoids” which are responsible for many of the vibrant colors found throughout nature. The placement and number of double bonds in a carotenoid’s molecular structure determines its color. Two examples include: red for lycopene and yellow for lutein. Some key contributions of lycopene include skin health, heart health, and cellular health

CoQ10
CoQ10 is found primarily in the mitochondria of cells to generate energy (among other functions). The body’s natural production of CoQ10 decrease with age, and food sources provide only insignificant amounts, making it all the more important to supplement with CoQ10. Some of the key contributions include metabolic health, physical performance, and heart health.

ROSEMARY

Rosemary is often seen in herb gardens. It is a fragrant culinary herb used in Mediterranean cuisine; it contains an active compound known as carnosic acid. Did you know that Greek scholars believed that wearing aromatic rosemary while studying helped to increase concentration? Modern science has investigated rosemary for its cognition and mood promoting benefits. Some key contributions of rosemary include brain health, cellular health, and heart health.

The seven ingredients we’ve highlighted here are part of a larger blend of innovative ingredients that make up ageLOC Youth. Each of these ingredients has its own unique set of benefits when considered alone. Together, they are even more effective. When combined into a single supplement, this unique blend of ingredients works synergistically to modulate gene expression to support six categories of Aging Defense Mechanisms in every cell and system of the body. ageLOC Youth is a revolutionary supplement designed to promote your youth span – the years you can enjoy life being more active, energetic, and healthy.

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Nu Biome

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Gut check: intestinal unease getting you down? From aiding digestion to helping maintain your overall gut health, the microorganisms in your GI tract impact your wellness far beyond your stomach. Pharmanex Nu Biome helps support this vital intestinal balance with a powerful dual-action solution of pre- and postbiotics, plus a healthy boost of caffeine for added energy. All in a delicious powder mix-in, so you can quickly and conveniently support your intestinal microbiome and feel your best every day.
• Helps harness the benefits of a healthy microbiome through a dual approach using pre- and postbiotics.*
• Supports a healthy balance of good and bad bacteria for improved intestinal health.*
• Helps maintain healthy digestion.*
• Helps maintain healthy energy levels.*
• Supports your body’s important antioxidant network.*
• Free from artificial colors, flavors, and sweeteners.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
How does Nu Biome support the antioxidant network?
Nu Biome contains a standardized whole fruit extract of Pomegranate that provides a high
concentration of polyphenols to support your antioxidant defense against oxidative stressors.
Antioxidants work together in the body – that’s why they are referred to as a network. These
antioxidants help to combat and neutralize a wide range of free radicals. Polyphenols are part of
this network to support our antioxidant defenses.
Why does Nu Biome contain caffeine?
Although the focus of the product is the microbiome and digestive health, we wanted to include
caffeine as a healthy source of energy to help people feel a difference. The digestive health
benefits may take some time to be realized, so the immediate energy benefit of caffeine may help motivate consumers to continue taking the product.
Is Nu Biome safe for children?
Nu Biome is formulated for adults ages 18+. We have not done studies on the effects of Nu Biome
on children. Due to the caffeine content, please consult a physician before giving Nu Biome
to a minor.
What are the sources of XOS and BPL1?
XOS is derived from corn cob. BPL1 was originally isolated from healthy humans and is produced
through a carefully controlled fermentation process.
Does Nu Biome help with leaky gut, IBS, IBD, gout, Chron’s, or other medical conditions?
Although Pharmanex products are carefully formulated to be safe and effective when used as
directed, they are not intended to be used to diagnose, treat, or cure any disease or medical
condition. Individuals with medical conditions are advised to consult a physician before using Nu
Biome or before starting any new dietary supplement.
Can I take Nu Biome and ProBio PCC together?
Yes! Nu Biome and ProBio PCC are great to take together. ProBio PCC is a living beneficial
microorganism that colonizes in the gut to support your wellness, providing complementary
support for a healthy microbiome. Nu Biome provides a powerful prebiotic that promotes
beneficial bacteria in the gut to support a healthy microbiome and improved intestinal health.
These products can each be taken on their own for their unique targeted digestive benefits or
together for more comprehensive support.
What is the difference between ageLOC Meta, ProBio PCC, and Nu Biome?
ageLOC Meta provides anthocyanins that help promote a healthy microbiome and ultimately help support metabolic health. ProBio PCC contains living beneficial microorganisms that colonize in the gut to support a protective immune response. Nu Biome provides a powerful prebiotic that promotes beneficial bacteria in the gut to support a healthy microbiome and improved intestinal health. All three of these products can be taken together or individually depending on the desired results.
What are some of the limitations of probiotics?
Not all probiotics are created equal. Probiotics can be beneficial, but they also have some
key limitations. Certain factors can limit the viability of a probiotic, including the acidity of
the product, the presence of other bacteria, processing and storage conditions, and resiliency
of the probiotic strain. Resilience refers to its ability to colonize the gut after passing through
the acidic environment of the stomach. Additionally, to be effective, probiotics need to have
excellent stability throughout the shelf life.
If I already take a probiotic, do I need to take Nu Biome too?
Probiotics work through a different mechanism than the ingredients in Nu Biome. A highquality probiotic (one that has excellent stability throughout its shelf life, survives passage
through the acidic environment of the stomach, colonizes in the lower digestive tract, and is
backed by clinical studies) provides beneficial bacteria that confer health benefits by colonizing
in the gut. Nu Biome works by providing prebiotics that act as fuel to support the growth
and activit.

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Specially designed for individuals who engage in physical exercise or physical work

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OverDrive provides B-vitamins, antioxidants, mineral cofactors, proteolytic enzymes, and electrolytes for energy metabolism and post-exercise muscle recovery. A complement of B-vitamins help assist the body’s normal biochemical processes during exercise, including nerve function and proper metabolism of fats, carbohydrates, and proteins* Includes three phytonutrient sources of powerful antioxidants: grape seed extract, citrus bioflavonoids, and quercetin, a flavonoid with powerful antioxidant activity Contains n-Acetyl-L-Cysteine, an important amino acid used by the body as a building block for the body’s powerful antioxidant, glutathione* Provides magnesium, which plays a key role in muscle energy transfer reactions* Contains proteolytic enzymes.

*These statements have not been evaluated by the Food and Drug Administration. this product is not intended to diagnose, treat, cure, or prevent any disease.
NOTE: Pregnant or lactating women, diabetics, hypoglycemics, and people with known medical conditions should consult with a physician prior to taking supplements.

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Scientific Studies

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Fatty acids

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Just ask actor Tom Cruise.He understands. I’m not saying that it’s this product, but he knows.
His coach understands the challenges. Fatty acids are dietary nutrients important for the healthy function of key structures and systems in the body. Two particularly important categories of fatty acids, classified as essential for health, are the omega-6 and omega-3 fatty acids. Unlike other fatty acids created by the body, omega-6
and omega-3 fatty acids can only be obtained from our diet. Typically, foods that contain or are prepared with vegetable oils are rich in omega-6 fatty acids while the primary dietary source of omega-3 fatty acids is fatty fish. A healthy diet should include a balance of omega-6 and
omega-3 fatty acids. Regrettably, many Western diets often include too many fried, fatty foods while not including the frequent consumption of fish, leading to an unhealthy fatty acid ratio low in omega-3 fatty acids. Increasing dietary intake of omega-3 fatty acids while reducing omega-6 intake will help restore a healthy fatty acid ratio. The scientific evidence supporting the health benefits of omega-3 fatty acids is immense. More than 100,000 scientific studies have been published on the health benefits of fish and fish oil. From helping to balance the body’s natural
immune response to supporting brain and cardiovascular functions, omega-3s have been widely proven in the scientific community.

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Krill Oil

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Results: In 70 patients with complete data, a statistically significant improvement was demonstrated among baseline, interim, and final evaluations in the self assessment questionnaire (P < 0.001) within the NKO group as well as between-group comparison to fish oil, after three cycles or 45 and 90 days of treatment. Data analysis showed a significant reduction of the number of analgesics used for dysmenorrhea within the NKO group (comparing baseline vs. 45- vs. 90-day visit). The between-groups analysis illustrated that women taking NKO consumed significantly fewer analgesics during the 10-day treatment period than women receiving omega-3 fish oil (P < 0.03).

Conclusion: Neptune Krill Oil can significantly reduce dysmenorrhea and the emotional symptoms of premenstrual syndrome and is shown to be significantly more effective for the complete management of premenstrual symptoms compared to omega-3 fish oil.

https://pubmed.ncbi.nlm.nih.gov/12777162/

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MarineOmega

ageLOC R2 Day Conserved 57% Muscle Glycogen

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Results: In mice, treatment with Cs4+PG+PFE spared glycogen in gastrocnemius muscle (p=0.003). These results demonstrate that targeting the genetic basis of the aging process (changes in gene expression), can yield powerful anti-aging benefits. This work
indicates that a blend of Cs4+PG,+PFE can alleviate some of the physical symptoms of age-related vitality loss.In a human cognitive study, male and female human subjects aged 28–50 were randomized into four independent arms (n=10/group): 1. Positivecontrol : 200mg Phosphatidylserine DHA , 300mg Bacopan, 30mg Vinpocetine (Gold); 2. ageLOC R 2 Day blend: 2270 mg/day (Cs-4+PG+PFE ); 3. Placebo: mono-crystalline cellulose, caramel color; 4. Nosupplementation. Subjects underwent cognitive testing (designed by MyBrainTrainer.com) twice a week for 12 weeks. Parameters measured: 3-choice reaction time, short term memory, executive function, information processing, pattern recognition, and working memory. The six scores were averaged to generate a Composite Cognition Index (CCI). In humans, treatment with Cs4+PG+PFE (ageLOC R 2 blend) improved overall cognitive function by 20% (as measured by the CCI), and improved reaction time by 110 ms (14%) vs. placebo (p<0.05).

Click to access ageLOC%20R2%20Day%20-%20Clinical%20Study.pdf

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Aging is associated with the accumulation of cellular toxins and damage.

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Aging is associated with the accumulation of cellular toxins and damage. Declines in cellular detoxification mechanisms and impairments in antioxidant protection are consistently
observed in aging models and likely contribute to ageassociated accumulation of cellular damage. The master regulator, Nuclear factor erythroid 2-related factor 2 (Nrf2), is a transcription factor that regulates the basal and inducible expression of a large battery of genes encoding for
cytoprotective factors including those that defend against electrophilic stressors and oxidative insults. The Nrf2/electrophile response element (EpRE) Antioxidant Protection and Phase II Detoxification pathways are impaired with aging due to age-related changes in gene expression (2). A key example is the reduction in glutathione (GSH) levels in all tissues with age due primarily to declines in glutamatecysteine ligase and glutathione synthase expression (1). Opposing these changes in gene expression may delay or attenuate the aging process. Most anti-aging intervention strategies to date, have tested single ingredients and have focused solely on an individual gene, in an isolated tissue. A more comprehensive strategy is to examine changes in the expression patterns of multiple genes or pathways in specific tissues and then to identify a
blend of phytochemicals that opposes those age-related changes. It seems prudent to examine changes that occur during middle age rather than waiting until old age when an intervention may not be as impactful. Accordingly, the purpose of this study was to test a blend of natural
compounds in middle-aged mice, compared to young mice, for the ability to oppose age-related changes in the expression of Nrf2-regulated genes involved in the detoxification of xenobiotics and xenobiotic metabolites and in the synthesis and regulation of intrinsic antioxidants and
antioxidant enzymes.

Click to access R2%20Society%20for%20Free%20Radical%20Research%20International%20Poster%2c%20London%2c%20Mastaloudis%202012.pdf

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R2 day 6 capsule and night 2 capsule

CORDYCEPS SINENSIS CS-4 IN OXIDATIVE STRESS AND AGING MODELS

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Cordyceps sinensis has traditionally been used in China as a strategy to combat aging. We have reported the e ects of Cordyceps sinensis Cs-4 (Cs-4) a mycelia fermentation product of C. sinensis, in glucose-lipid-energy metabolisms, anti-fatigue, and endurance enhancement. In this study, we examined the e ect of Cs-4 on lifespan extension and antioxidant status in mice. For the lifespanextension study, 250 mice 12 months of age (both sexes) received either vehicle or Cs-4 (0.5, 1.0 or 1.5g/kg diet). Caloric intake was adjusted to match the levels for controls twice per week. Compared to controls, the Cs-4 dosage group’ s 75% survival time was extended 94-108 days, 50% survival time extended 10-66 days, 25% survival time extended 29–44 days, and 12.5% survival time extended 7–50 days (86 weeks so far; treatment continues). The Kaplan-Meier Survivor analysis revealed the extended lifespan and the reduced risks of death by Cs-4. The antioxidant activity was tested in mice (6 months old) that received 60 days of vehicle or Cs-4 (0.5, 1.0 or 1.5 g/kg diet) and a single dose of 11Gy 60Co gamma-radiation on day 60. Compared to controls, Cs-4 prevented the depletion of plasma total thiol-groups, GSH and GSH-peroxidase, liver CAT, SOD, and GSH-reductase (p<0.05) caused by radiation exposure. Cs-4 also prevented the radiation-induced increases in liver protein carbonyls and 8-OHdG (p<0.05) observed in the control group. In conclusion, Cs-4 supplementation signifi cantly improves the body’s antioxidant capacity and extends the lifespan in mice, supporting the traditional anti-aging uses of Cs-4 in humans.

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CordyMax Cs-4

Nutrient

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Nutrient blend EPA+DHA ultra-pure fish oil concentrate, resveratrol (from Polygonum cuspidatum root), quercetin (from Dimorphandra mollis fruit extract), purple corn (Zea mays L.) cob extract, rosemary (Rosmarinus officinalis L.) leaf extract, citrus bioflavonoids (naringin and hesperidin), coenzyme Q10, alpha lipoic acid, astaxanthin (a carotenoid from Haematococcus pluvialis algae), lycopene (a carotenoid), lutein (a carotenoid from Marigold flower (Targetes erecta)), vitamin D3 (as cholecalciferol), vitamin K2 (as menaquinone-7), and d-limonene (from citrus sinensis peel oil). Magnetic Resonance Imaging (functional MRI). Functional MRI (fMRI) examines the connectivity between brain regions. In particular, resting state connectivity can be a valuable tool to examine parameters of connectivity due to the stability of the connectivity during the resting state. RESULTS The Figures below illustrate the right orbitofrontal cortex (OFC) seed region. There was a decrease in connectivity relative to baseline and relative to placebo, respectively. This reduction in connectivity allows for additional channels to exist for increased intake of new data. These findings show a significant reduced intrinsic coupling between the right OFC brain region and the clusters in precentral, paracentral, parietal, supplementary motor, precuneus, and frontal cortical regions.

Click to access Alterations%20in%20Brain%20Connectivity%20Following%20Supplementation.pdf

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AGING

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Abstract.

Aging is characterized by a gradual loss in physical and mental function starting at 30-40 years of age. Thepurpose of this study was to compare a novel combination of Cordyceps sinensis, pomegranate extract, andPanax ginseng (TRT) to control (CNTL) formula regarding physical, mental, and sexual desire. Healthy malesand female subjects (n=116) were recruited to participate in a prospective, double-blind, randomized,placebo-controlled trial that lasted 60 days. Subjects were randomized into a control (n= 56; CNTL) ortreatment (n= 60; TRT) groups and stratified by age and gender. Mental (MCS) and physical (PCS) wellbeing were measured by validated questionnaires. Other measurements included blood chemistry measurements,
skin carotenoid concentrations, and adverse events. There were n=48 in CNTL and n=47 in TRT groups that completed the study. No differences were detected in the mean scores for (PCS=CNTL;-0.47, TRT;-0.08) or (MCS=CNTL;0.32, TRT;-1.98) and sexual desire between groups nor between age. There was a strong trend towards higher skin carotenoid concentrations in the TRT group (P=0.052). There was no difference between groups for adverse events or blood chemistry. The TRT formulation appears to be safe. We were unable to detect differences in physical, mental, and sexual desire as seen in animal studies presumably because this
population was so healthy and didn’t show an age related decline. There was an interesting finding that subjects consuming the TRT formulation experienced a trend towards higher skin carotenoid concentrations and warrants further investigation in a population which has age-related decline in physical, mental, sexual decline, or experiencing greater oxidative stress.
Research was supported by Nu Skin Enterprises, Provo, Utah

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R2 day