Tag: sex

Aging is associated with the accumulation of cellular toxins and damage.

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Aging is associated with the accumulation of cellular toxins and damage. Declines in cellular detoxification mechanisms and impairments in antioxidant protection are consistently
observed in aging models and likely contribute to ageassociated accumulation of cellular damage. The master regulator, Nuclear factor erythroid 2-related factor 2 (Nrf2), is a transcription factor that regulates the basal and inducible expression of a large battery of genes encoding for
cytoprotective factors including those that defend against electrophilic stressors and oxidative insults. The Nrf2/electrophile response element (EpRE) Antioxidant Protection and Phase II Detoxification pathways are impaired with aging due to age-related changes in gene expression (2). A key example is the reduction in glutathione (GSH) levels in all tissues with age due primarily to declines in glutamatecysteine ligase and glutathione synthase expression (1). Opposing these changes in gene expression may delay or attenuate the aging process. Most anti-aging intervention strategies to date, have tested single ingredients and have focused solely on an individual gene, in an isolated tissue. A more comprehensive strategy is to examine changes in the expression patterns of multiple genes or pathways in specific tissues and then to identify a
blend of phytochemicals that opposes those age-related changes. It seems prudent to examine changes that occur during middle age rather than waiting until old age when an intervention may not be as impactful. Accordingly, the purpose of this study was to test a blend of natural
compounds in middle-aged mice, compared to young mice, for the ability to oppose age-related changes in the expression of Nrf2-regulated genes involved in the detoxification of xenobiotics and xenobiotic metabolites and in the synthesis and regulation of intrinsic antioxidants and
antioxidant enzymes.

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R2 day 6 capsule and night 2 capsule

AGING

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Abstract.

Aging is characterized by a gradual loss in physical and mental function starting at 30-40 years of age. Thepurpose of this study was to compare a novel combination of Cordyceps sinensis, pomegranate extract, andPanax ginseng (TRT) to control (CNTL) formula regarding physical, mental, and sexual desire. Healthy malesand female subjects (n=116) were recruited to participate in a prospective, double-blind, randomized,placebo-controlled trial that lasted 60 days. Subjects were randomized into a control (n= 56; CNTL) ortreatment (n= 60; TRT) groups and stratified by age and gender. Mental (MCS) and physical (PCS) wellbeing were measured by validated questionnaires. Other measurements included blood chemistry measurements,
skin carotenoid concentrations, and adverse events. There were n=48 in CNTL and n=47 in TRT groups that completed the study. No differences were detected in the mean scores for (PCS=CNTL;-0.47, TRT;-0.08) or (MCS=CNTL;0.32, TRT;-1.98) and sexual desire between groups nor between age. There was a strong trend towards higher skin carotenoid concentrations in the TRT group (P=0.052). There was no difference between groups for adverse events or blood chemistry. The TRT formulation appears to be safe. We were unable to detect differences in physical, mental, and sexual desire as seen in animal studies presumably because this
population was so healthy and didn’t show an age related decline. There was an interesting finding that subjects consuming the TRT formulation experienced a trend towards higher skin carotenoid concentrations and warrants further investigation in a population which has age-related decline in physical, mental, sexual decline, or experiencing greater oxidative stress.
Research was supported by Nu Skin Enterprises, Provo, Utah

Click to access EB%202013%20Wood%20Vitality.pdf

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R2 day

pdr.net

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Text shared and quoted by pdr.net

“Trusted by generations of healthcare providers, PDR delivers innovative health knowledge products and services that support prescribing decisions and patient adherence to improve health. As a leading provider of behavior-based prescription management programs, PDR provides event-driven and clinically relevant healthcare messaging through its patented process that improves patient compliance and outcomes, while preserving privacy. This network is made up of e-prescribing, electronic medical record (EMR), and electronic health record (EHR) applications, chain and independent pharmacies, and sponsors of healthcare-related education such as pharmaceutical manufacturers, health plans, payers, and pharmacy benefit managers. The Physicians’ Desk Reference® suite of services provides healthcare professionals multichannel access to important drug information: the PDR®, the most recognized drug information reference available in the U.S.; interactive drug information services for EHR/EMR systems; digital communication services; PDR.net®; and mobilePDR®”

https://pdr.net/full-prescribing-information/ageLOC-R2-brassica-oleracea-italica-citrus-sinensis-vitis-vinifera-L—–mushroom-mycelia-panax-ginseng-punica-granatum-479

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R2 day

LIBIDO

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Source and sharing: https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/tribulus

“Tribulus
There is little information on the traditional use of tribulus leaf. In Ayurvedic medicine, the fruit has been used for improving male fertility and male erectile function, uterine disorders, urinary disorders, kidney stones, gout, and gonorrhea. As a result of Bulgarian research, tribulus has become a popular herb for the treatment of infertility, menopause, and low libido. It acts as a general tonic, aphrodisiac, and is used to restore vitality, reduce the physiologic effects of stress, and is a powerful fertility tonic for both men and women.

Open-label clinical trials have demonstrated improvements in both male and female infertility. Bulgarian research has identified a unique steroidal saponin known as a furostanol saponin, calculated to no less than 45% protodioscin. The leaf is noted to be higher in the unique saponin than the fruit.”

Bulgarian Tribulus terrestris

Gene expression profiling with DNA microarrays can measure

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Gene expression profiling of aging in multiple mouse
strains: identification of aging biomarkers and impact
of dietary antioxidants
Sang-Kyu Park,1, Kyoungmi Kim,2,Grier P. Page,2,
David B. Allison,2 Richard Weindruch3 and Tomas A.
Prolla
1Department of Genetics and Medical Genetics, University of
Wisconsin, Madison, WI 53706, USA2Department of Biostatistics, Section on Statistical Genetics andClinical Nutrition Research Center, University of Alabama,Birmingham, AL 35294, USA3Department of Medicine and Wisconsin Primate ResearchCenter,VeteransAdministration Hospital, University of Wisconsin,Madison, WI 53706, USA

 

Summary
We used DNA microarrays to identify panels of transcriptional markers of aging that are differentially expressed in young (5 month) and old (25 month) mice of multiple inbred strains (129sv, BALB ⁄ c, CBA, DBA, B6, C3H and B6C3F1). In the heart, age-related changes of five genes were studied throughout the mouse lifespan: complement component 4, chemokine ligand 14, component of Sp100-rs, phenylalanine hydroxylase and src family associated phosphoprotein 2. A similar analysis in the brain (cerebellum) involved complement component 1q (alpha polypeptide), complement component 4, P lysozyme structural, glial fibrillary acidic protein and cathepsin S.Caloric restriction (CR) inhibited age-related expression of these genes in both tissues. Parametric analysis of gene set enrichment identified several biological processes that are induced with aging in multiple mouse strains. We also tested the ability of dietary antioxidants to oppose these transcriptional markers of aging. Lycopene, resveratrol, acetyl-L-carnitine and tempol were as effective as CR in the heart, and a-lipoic acid and coenzyme Q10 were as
effective as CR in the cerebellum. These findings suggest that transcriptional biomarkers of aging in mice can be used to estimate the efficacy of aging interventions on a tissue-specific basis. Key words: aging; antioxidants; biomarkers; caloricrestriction; microarray; mouse.
FULL STUDY HERE:

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1474-9726.2009.00496.x

Based on the results, we offer 2 products.
First ageLOC R2 image (EU and US available)
Second image of ageLOC Youth (available in the USA)

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R2 day

Sexual desire

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” Aging is characterized by a gradual loss in physical and mental function starting at 30-40 years of age. The purpose of this study was to compare a novel combination of Cordyceps sinensis, pomegranate extract, and Panax ginseng (TRT) to control (CNTL) formula regarding physical, mental, and sexual desire. Healthy males and female subjects (n=116) were recruited to participate in a prospective, double-blind, randomized, placebo-controlled trial that lasted 60 days. Subjects were randomized into a control (n= 56; CNTL) or treatment (n= 60; TRT) groups and stratified by age and gender. Mental (MCS) and physical (PCS) wellbeing were measured by validated questionnaires. Other measurements included blood chemistry measurements,
skin carotenoid concentrations, and adverse events. There were n=48 in CNTL and n=47 in TRT groups that completed the study. No differences were detected in the mean scores for (PCS=CNTL;-0.47, TRT;-0.08) or (MCS=CNTL;0.32, TRT;-1.98) and sexual desire between groups nor between age. There was a strong trend towards higher skin carotenoid concentrations in the TRT group (P=0.052). There was no difference between groups for adverse events or blood chemistry. The TRT formulation appears to be safe. We were unable to detect differences in physical, mental, and sexual desire as seen in animal studies presumably because this population was so healthy and didn’t show an age related decline. There was an interesting finding that subjects consuming the TRT formulation experienced a trend towards higher skin carotenoid concentrations and warrants further investigation in a population which has age-related decline in physical, mental, sexual decline, or experiencing greater oxidative stress. Research was supported by Nu Skin Enterprises, Provo, Utah

Click to access EB%202013%20Wood%20Vitality.pdf

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10 times more

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Women/ on the arms, abdomen, buttocks and men/abdomen and breast.Result 6/8 weeks, at least 3 times a week.

Your body optimized. Nu Skin has captured the future of bodycare with the ageLOC® Galvanic Body Spa™. Ergonomically
designed for ease of use and handling during body treatments, the new ageLOC Galvanic Body Spa with pulsating technology features a proprietary ageLOC body conductive surface designed to deliver 10 times more ageLOC to your skin when used with ageLOC Body Shaping Gel. The ageLOC Galvanic Body Spa targets the ultimate sources of aging while diminishing
the appearance of fat and cellulite and smoothing skin to provide a slimmer, more toned appearance. It also features a self-adjusting current, lighted display, and audio indications, making it an easy to use in-home anti-aging body system. Newly developed, patent-pending galvanic pulsating technology is optimized to maximize anti-aging effects on the arms, abdomen, buttocks, and thighs. The skin on the body is thicker and less sensitive, making it benefit from and respond to a pulsating galvanic current. It also helps stimulate, purify, and refresh your skin to reduce the visible signs of aging—for a slimmer, smoother, firmer, youthful looking you today and in the future.
PRIMARY MARKETS

• Women and men looking for a firmed, toned, younger looking body.
• Current ageLOC Galvanic Body Spa and Galvanic Spa® customers

• Image conscious women, ages 25–65, who may occasionally visit day spas.
• Women of any age with cellulite and other signs of aging on the body.
• ageLOC® Body Shaping Gel—formulated to work exclusively with Nu Skin® Galvanic Spa® instruments to bring ageLOC anti-aging benefits to the body, smooth the appearance of fat and cellulite, and help refresh and purify the skin while reducing the visible signs of aging.
What is unique about the ageLOC Galvanic Body Spa?
The ageLOC Galvanic Body Spa was designed for use in combination with ageLOC Body Shaping Gel on body areas—not on the face and neck. This instrument was designed to target a larger surface area with a patentpending ageLOC conductive surface that captures 10 times more key ingredients between the conductive surface and the skin (when compared to the body conductor attachment). Secondly, this design is more ergonomic for easier use and handling during body treatments. Thirdly,
the ageLOC Galvanic Body Spa and ageLOC Body Shaping Gel target end benefits/results (i.e., appearance of cellulite, slimming, toning, etc.) that are different from those targeted on the face. Lastly, the skin on the body is thicker and less sensitive, making it more apt to benefit from and respond to a pulsating current.
What is the difference between a pulsating galvanic
current and a constant galvanic current?
A constant galvanic current is one that has a steady flow. It does not waver or vary in amplitude. A pulsating galvanic
current is one that varies between two different, pre-established levels. Please note these are very different than alternating currents (AC). Within alternating currents, the polarity fluctuates between positive and negative poles. A pulsating galvanic current is better suited for the body.
What is the benefit of using a pulsating galvanic current
on the body?
Direct (galvanic) currents, whether pulsating or not, can assist in the delivery of like charged key ingredients to the skin by improving osmotic flow. This is increasingly important for enhancing delivery of key ingredients to areas with thicker skin. Additional research has shown that the pulsating current enhances fluid vibration. Pulsating galvanic currents aid in stimulating skin and increasing cellular communication to help purify and refresh skin and help reduce the visible signs of skin aging.
Pulsating galvanic currents are optimally designed for use on the body where the skin can benefit from enhanced fluid vibration.
What is the benefit of having a grooved body
conductive surface?
The patent-pending grooved ageLOC conductive surface captures 10 times more key ingredients in the critical area between the conductive surface and the skin (when compared to the body conductor attachment).
How much pressure should I apply?
Nu Skin’s Galvanic Spa instruments should be very gently used with light pressure. There is no need to apply pressure
to get the maximum benefits. The galvanic currents do the work for you.

Should the ageLOC Galvanic Body Spa be used on the face?
No. The ageLOC Galvanic Body Spa was not designed for use on the face and neck. This instrument was designed specifically for use on the body. It easily treats a larger surface area, easily follows the contours of the body, and, when combined with ageLOC Body Shaping Gel, brings about the targeted end results (i.e., diminishing appearance of cellulite, smoothing skin, slimming, toning,
etc.).

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