Concentrated extract

Tegreen 97 is a proprietary, highly concentrated extract of polyphenols, a large percentage of which are antioxidant catechins found naturally in green tea that promote long-term cellular health.
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The whole study with the authors here:Sartippour MR, Pietras R, Marquez-Garban DC, Chen HW, Heber D, Henning SM, Sartippour G, Zhang L, Lu M, Weinberg O, Rao JY, Brooks MN. Carcinogenesis. 2006 Dec;27(12):2424-33.
“Epidemiologic data have suggested that green tea mayprevent breast cancer. Studies in our laboratory haveprovided evidence that green tea extract inhibits breastcancer growth by a direct anti-proliferative effect on thetumor cells, as well as by indirect suppressive effectson the tumor-associated endothelial cells. In this study, weasked whether concurrent administration of green tea may add to the anti-tumor effects of standard breastcancer therapy. We observed that green tea increased theinhibitory effect of tamoxifen on the proliferation of theER (estrogen receptor)-positive MCF-7, ZR75, T47Dhuman breast cancer cells in vitro. This combinationregimen was also more potent than either agent alone atincreasing cell apoptosis. In animal experiments, mice treated with both green tea and tamoxifen had the smallest MCF-7 xenograft tumor size, and the highest levels of apoptosis in tumor tissue, as compared with either agent administered alone. Moreover, the suppression of angiogenesis in vivo correlated with larger areas of necrosis and lower tumor blood vessel density in treated xenografts. Green tea decreased levels of ER-a in tumors both in vitro and in vivo. We also observed that green tea blocked ER-dependent transcription, as well as estradiolinduced phosphorylation and nuclear localization of mitogen-activated protein kinase. To our knowledge, this study is the first to show the interaction of green tea with the ER pathway, as well as provide mechanistic evidence that the combination of green tea and tamoxifen is more potent than either agent alone in suppressing breast cancer growth. These results may lead to future improvements in breast cancer treatment and prevention.”

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